Ongoing Stem Cell Research Projects
2015 External Funding
|
No |
Project Title |
Funding amount (RM) |
Principal Investigator |
Co-investigators |
Funding Agencies |
|
1 |
Development and characterisation of osteosarcoma-derived induced pluripotent stem cell for disease modelling |
400,000 |
Emeritus Prof Dr. Cheong SK |
Prof Dr. Choo KB, Prof Tunku Kamarul |
UM HIRG |
|
2 |
Cell-based gene therapy – Phase 2 Studies |
300,000 |
Emeritus Prof. Dr. Cheong SK |
Prof. Dr. S Fadilah AW, A/P Dr. Leong CF, Dr. Maha A |
MAKNA |
|
3 |
Aging of human mesenchymal stem cells (MSCs): Genomic and epigenomic analysis and applications |
400,000 |
Prof Dr Choo KB |
Emeritus Prof Dr. Cheong SK, Prof Tunku Kamarul |
UM HIRG |
|
4 |
iPSC from bone marrow-derived MSC: Epigenetic regulation of cellular reprogramming |
400,000 |
Prof Dr Choo KB |
Emeritus Prof Dr. Cheong SK, Prof Tunku Kamarul |
UM HIRG |
|
5 |
Profiling of microsatellite alterations from human adult mesenchymal stem cell sources in relation to cell senescence and cell population level variation |
300,000 |
Assoc Prof Dr Alan Ong HK |
Emeritus Prof Dr. Cheong SK, Prof Tunku Kamarul, Dr Lim Kian Lam |
UM HIRG |
|
6 |
Development of combination therapies targeting breast cancer stem cells |
294, 000 |
Assoc. Prof. Dr. Leong Chee Onn |
Emeritus Prof. Dr. Cheong SK, Prof. Dr. Lim YM, Prof. Dr. Anthony Ho, Prof. Dr. Teo SH |
ERGS |
|
7 |
Molecular population genetics of potential microsatellite markers for Southeast Asian Crocodile, Tomistoma shchlegelii |
2500 |
Assoc. Prof. Dr. Alan Ong HK |
- |
BOH plantations |
|
8 |
Elucidating the transcription mechanism of chromosome 19 microRNA cluster (C19MC) in regulating self-renewal of induced pluripotent stem cells (iPSCs) |
131,200 |
Prof. Dr. Choo KB |
Dr. Chew CH, Dr. Leong PP |
FRGS |
|
9 |
Decoding the differentiation of mesenchymal stem cells to mesangial cells at transcriptomic level |
15,000 |
Prof. Dr. Lim Yang Mooi |
Emeritus Prof. Dr. Cheong SK |
Malaysian Toray Science Foundation |
|
10 |
Analysis of exosomal miRNA expression of BM-MSCs and their influence of osteosarcoma-derived CSC-like population (CD133+) |
30,000 |
Norlaily Mohd Ali |
Assoc. Prof. Dr. Alan Ong HK |
MAKNA |
|
2015 Internal Funding (UTARRF) |
||||
|
No |
Project Title |
Project Leader |
Co-Investigator |
Funding amount (RM) |
|
1 |
Differentiation of Human Keratinocyte-derived Reprogrammed Cells Into Neuroectodermal Lineage |
Assoc. Prof. Dr. Gan Seng Chiew |
Assoc. Prof. Dr. Alan Ong HK, Dr. Rachel Mok |
8,000 |
|
2 |
Profiling of miRNAs and microsatellite alterations from human adult MSCs bone marrow in relation to aging, prolonged passage and hypoxia |
Assoc. Prof. Dr. Alan Ong HK |
Emeritus Prof. Dr. Cheong SK, Prof Dr. Khoo SP, Dr. Yeap SK |
92,500 |
|
3 |
Hypermethylation, miRNA and chemotherapeutic drugs profiling of the spheroid derivatives from human breast cancer cell lines |
Assoc. Prof. Dr. Alan Ong HK |
Emeritus Prof. Dr. Cheong SK, Dr. Yeap SK |
84,500 |
|
4 |
Use of biomarkers for the early detection and prediction of clinical dengue cases. |
Dr Gary Low Kim Kuan |
A/P Dr. Gan SC, Prof. Dato’ Dr. Lye MS, Prof. Dr. Zamberi S |
90,000 |
|
5 |
Expression of Sensor Protein in Nasopharyngeal Carcinoma |
Assist. Dr. Leong Pooi Pooi |
- |
41,000 |
|
6 |
Prevalence of Vitamin D Deficiency and its Association with Metabolic Syndrome amongst the Malay Overweight/Obese Adolescents in Klang Valley |
Ms Chew Wai Fong |
Prof Boo NY, Dr Leong PP, A/P Dr Chee W |
109,617 |
|
7 |
Development of chemoresistant colorectal cancer stem cell model |
Prof. Dr Shelly Soo |
Prof. Dr. Choo KB |
77,000 |
|
8 |
Regulation of self-renewal by microRNA-515 gene family in induced-pluripotent stem cells (iPSCs) |
Prof. Dr. Choo KB |
Prof. Dr. Huang CJ, Assist. Prof. Dr. S. Sugii |
81,500 |
|
9 |
Investigating the role of secreting proteins of human adipose-derived mesenchymal stem cells for the maintenance of human pluripotency stem cell culture |
Assist. Dr. Leong Pooi Pooi |
Prof. Boo NY |
53,000 |
|
10 |
Induction of dermal papilla properties in mesenchymal stem cells by using 3D culture |
Assoc. Prof. Dr. Gan Seng Chiew |
Assoc. Prof. Dr. Alan Ong HK |
32,800 |
|
11 |
Identification of areas of occurrence, census and genetic diversity using microsattelite markers of tomistoma schlegelii in Peninsular Malaysia |
Assoc. Prof. Dr. Alan Ong HK |
- |
93,810 |
|
12 |
MicroRNA expression profiling of colorectal cancer (CRC)- reprogrammed induced pluripotent cancer (iPC) cells in relation to self-renewal |
Prof. Dr. Choo KB |
Prof. Dr. Huang CJ |
92,000 |
|
13 |
Establishment and characterisation of primary spheroidal cancer stem cell cultures of surgically resected colorectal cancer tissues |
Prof. Dr. Shelly Soo |
Prof. Dr. Choo KB |
93,000 |
| Research Projects in 2014 | ||||
| 2014 External Funding | ||||
|
No |
Project Title |
Project Members |
Funding amount |
Funding source/agencies |
|
1 |
Aging of human mesenchymal stem cells (MSCs): Genomic and epigenomic analysis and applications |
Prof Dr Choo Kong Bung (PI) |
RM 400,000 |
UM HIRG |
|
2 |
iPSC from bone marrow-derived MSC: epigenetic regulation of cellular reprogramming
|
Prof Dr Choo Kong Bung (PI) |
RM 400,000 |
UM HIRG |
|
3 |
Elucidating the transcription mechanism of chromosome 19 microRNA cluster (C19MC) in regulating self-renewal of induced pluripotent stem cells (iPSCs)
|
Prof Dr. Choo Kong Bung (PI) Dr. Chew Choy Hoong Dr. Leong Pooi Pooi |
RM 131,200 |
FRGS, HoE |
|
4 |
Deciphering of cellular receptor responsibile for Pteropine othoreovirus gaining entry into host
|
Dr. Kenny Voon (IMU) PI Dr. Leong Pooi Pooi (UTAR) |
RM 100,000 |
MOE |
|
6 |
Molecular population genetics of potential microsatellite markers for Southeast Asian Crocodile, Tomistoma shchlegelii |
Assoc. Prof. Dr. Alan Ong |
RM 2,500 |
BOH plantations |
|
7 |
2-methoxy-1,4 naphthquinone (MNQ) in regulating protein kinase C and its downstream signaling pathway
|
Gan Seng Chiew (PI) Lim Yang Moi & Antony Loke |
RM135,500 |
FRGS |
|
8 |
Cell-based gene therapy – Phase 2 Studies |
Prof. Dr. SK Cheong (PI) |
RM 300,000
|
MAKNA |
|
9 |
Mesenchymal stem cell – Biology & application |
Prof. Dr. SK Cheong (PI) |
RM 1,000,000
|
Scientex Foundation (Via MAKNA) |
|
10 |
Development and characterisation of osteosarcoma-derived induced pluripotent stem cells for disease modelling |
Prof. Dr. SK Cheong (PI)
|
RM 400,000 |
UM HIRG |
|
11 |
Profiling of microsatellite alterations from human adult mesenchymal stem cell sources in relation to cell senescence and cell population level variation
|
Assoc. Prof. Dr Alan Ong (PI)
|
RM 300,000 |
UM HIRG |
|
12 |
Development of combination therapies targeting breast cancer stem cells |
Prof. Dr. SK Cheong |
RM 294,000 |
ERGS, MOE |
|
13 |
Effect of edible bird nest on global gene expression and differentially expressed proteins on human mesenchymal stem cells |
Prof. Dr. SK Cheong
|
RM 30,000 |
Royal Bird Nest Sdn. Bhd. |
|
14 |
Decoding the differentiation of mesenchymal stem cells to mesangial cells at transcriptomic level
|
Prof. Dr. SK Cheong
|
RM 15,000 |
Malaysian Toray Science Foundation |
2014 Internal Funding
|
No |
Project Title |
Project Members |
Funding amount |
|
1 |
Regulation of expression of microRNA-515 gene family in induced-pluripotent stem cells (iPSCs)
|
Prof Dr Choo KB (PI) Prof Dr Huang Chiu-Jung Assist Prof Dr S. Sugii |
RM 101,000 |
|
2 |
Regulation of self-renewal by microRNA-515 gene family in induced-pluripotent stem cells (iPSCs) |
Prof Dr Choo KB (PI) Prof. Dr Huang Chiu-Jung Emeritus Prof Dr Cheong Soon Keng |
RM 81,200 |
|
3 |
Cellular reprogramming based on the C19MC microRNA cluster
|
Prof Dr Choo KB (PI) Dr. Leong Pooi Pooi |
RM 44,400 |
|
4 |
Generation of glucose-6-phosphate dehydrogenase (G6PD) deficiency-derived induced pluripotent stem cell (iPSC) from Peripheral Blood Mononuclear Cells
|
Dr Leong Pooi Pooi (PI) Dr. Alan Ong Han Kiat Prof Cheong Soon Keng Prof Dr. Boo Nem Yun |
RM 34,216 |
|
5 |
Targeted Screening of Bio-Active Compounds using a Multi-Purpose Cervical Cancer Cell-Based System |
Prof Yap SF (PI) Dr Leong PP Prof Ngeow YF (UM) Prof Chung LY (UM) Dr Kiew LV (UM) Dr Kenneth Raj (HPA, UK) |
RM 56,000 |
|
6 |
Investigation of HPV-induced susceptibility to chemotherapeutic agents using the primary cervical cell model |
Prof Yap SF (PI) Prof Choo KB Dr Leong PP Prof Ngeow YF (UM) Prof Dr Kenneth Raj (HPA, UK) |
RM 68,000 |
|
7 |
Expression of Sensor Protein in Nasopharyngeal Carcinoma |
Dr Leong PP (PI) |
RM 41,000 |
|
8 |
Prevalence of Vitamin D Deficiency and its Association with Metabolic Syndrome amongst the Malay Overweight/Obese Adolescents in Klang Valley
|
Ms Chew WF (PI) Prof Boo NY Dr Leong PP A/P Dr Winnie Chee (IMU) |
RM 109,617 |
|
9 |
Clinical research on Traditional Chinese Medicine (TCM) treatment of dry eye syndrome |
Dr Yang Z Prof Choo KB Dr Leong PP Mr Wang CZ Ms Lim CB |
RM 15,000 |
|
10 |
Profiling of miRNAs and microsatellite alterations from human adult MSCs bone marrow in relation to aging, prolonged passage and hypoxia |
Dr. Alan Ong (UTAR) Prof Dr. Cheong Soon Keng Prof Dr. Khoo Suan Phaik (IMU) Dr. Yeap Swee Keong (UPM) |
RM 92,500 |
|
11 |
Hypermethylation, miRNA and chemotherapeutic drugs profiling of the spheroid derivatives from human breast cancer cell lines
|
Dr. Alan Ong (PI) Prof Dr. Cheong Soon Keng Dr. Yeap Swee Keong (UPM) |
RM 84,500 |
|
12 |
Differentiation of Human Keratinocyte-derived Reprogrammed Cells Into Neuroectodermal Lineage
|
A/P Dr Gan Seng Chiew A/P Dr Alan Ong Han Kiat Dr. Rachel Mok (UPM) |
RM 8,000 |
|
13 |
Effects of High Fidelity Patient Simulators (HFPS) as Teaching Learning Strategy on Learning Outcomes and Critical Thinking Skills Among Year-3 Diploma Nursing Students In Malaysia |
A/P Dr. Gan Seng Chiew Ms Fong Ka Ling A/P Dr. Khatijah Binti Abdullah @ Lim Geok Khim (MU) A/P Dr Wong Li Ping (MU) |
RM 29,522.56 |
|
14 |
Use of biomarkers for the early detection and prediction of clinical dengue cases. |
A/P Dr. Gan Seng Chiew ( Dr Gary Low Kim Kuan Prof. Dato’ Dr. Lye Munn Sann (UPM) Prof. Dr. Zamberi Sekawi (UPM) |
RM 90,000 |
|
15 |
Thermosensitive microcarriers for non-invasive detachment of anchorage-dependent human mesenchymal stem cells |
Prof SK Cheong Prof Dr Lim Yang Mooi (PI) |
RM 64,000 |
Research Projects in 2013
2013 External Funding
|
No |
Project Title |
Project Members |
Funding amount |
Funding source/agencies |
|
1 |
Identification of breast and prostate cancer stem cell DNA marker and evaluation of chemotherapeutic drugs on derived cancer stem cells
|
Prof. Dr. Cheong SK (UTAR) Prof. Dr. Abdul Rahman bin Omar (UPM) A/Prof. Dr. Noorjahan Banu binti Moha (UPM) Dr. Chong LK (MUST) |
RM 214,000 |
EScience (MOSTI) |
|
2 |
Profiling of microsatellite alterations from human adult mesenchymal stem cell sources in relation to cell senescence and cell population level variation |
Prof. Dr. Cheong SK (UTAR) Prof. Dr. Tunku Kamarul (UMMC) Dr. Lim KL (Cytopeutics)
|
RM 300,000 |
UM-UTAR HIRG |
|
3 |
Mesenchymal stem cell – Biology & application |
Prof. Dr. Cheong SK (UTAR/team leader) A/Prof. Dr. Leong Chooi Fun (UKM) Prof. Dr. Fadilah Abdul Wahid (UKM) Ms. Teoh HK (MAKNA Res Inst) |
RM 1 million |
Scientex Foundation (Via MAKNA) |
|
4 |
Induced pluripotent stem cells from bone marrow-derived mesenchymal stem cells: Epigenetic regulation of cellular reprogramming |
Prof. Dr. Choo KB (UTAR/PI) Prof. Dr. Cheong SK (UTAR) Prof. Dr. Tunku Kamarul (UMMC) Ms. Nguyen Nhi (UTAR) |
RM 400,000 |
H-50001-00-A000003/UTAR1 |
|
5 |
Development and characterisation of osteosarcoma-derived induced pluripotent stem cells for disease modelling |
Prof. Dr. Cheong SK (UTAR/PI) A/Prof. Dr. Alan Ong (UTAR) Prof. Dr. Tunku Kamarul (UMMC) Ms. Erica Choong (MAKNA Res Inst) |
RM 400,000 |
H-50001-00-A000003/UTAR2 |
|
6 |
Aging of human mensenchymal stem cells: Genomic and epigenomic analysis |
Prof. Dr. Choo KB (UTAR/PI) Prof. Dr. Cheong SK Prof. Dr. Tunku Kamarul (UMMC) Ms K. Shri Hymavathee(UTAR) |
RM 400,000 |
H-50001-00-A000003/UTAR3
|
|
7 |
Profiling of microsatellite alterations from human adult mesenchymal stem cell sources in relation to cell senescence and cell population level variation |
A/Prof. Dr. Alan Ong (UTAR/PI) Prof. Dr. Cheong SK (UTAR) Prof. Dr. Tunku Kamarul (UMMC) Dr. Lim KL (MUST) |
RM 300,000 |
H-50001-00-A000003/UTAR4 |
|
8 |
Effect of edible bird nest on global gene expression and differentially expressed proteins on human mesenchymal stem cells |
A/Prof. Dr. Lim YM (UTAR/PI) Prof. Dr. Cheong SK (UTAR)
|
RM 30,000 |
Royal Bird Nest Sdn. Bhd. |
2013 Internal Funding
|
No |
Project Title |
Project Members (UTAR except specified) |
Funding amount |
|
1 |
Development and characterisation of spheroids (tumour spheres) and viral mediated reprogrammed cancer cells derived from human oral primary cancer cells |
Prof. Dr. Cheong SK (PI) Prof. Dr. Khoo SP (IMU) Dr. Yeap SK (UPM) |
RM 61,200 |
|
2 |
3D culture and expansion of human mesenchymal stem cells with novel microcarriers |
A/Prof. Dr. Lim YM (PI) Prof. Dr. Cheong SK |
RM 105,922 |
|
3 |
A preliminary study on the effect of edible bird nest on the neuron stem cells |
A/Prof. Dr. Lim YM (PI) Prof. Dr. Cheong SK |
RM 103,000 |
|
4 |
Development and characterisation of prostate cancer cell-derived induced pluripotent stem cell for disease modeling and cancer therapy |
A/P Dr. Alan Ong (PI) Prof. Dr. Cheong SK Ms. Teoh HK (MAKNA Res. Inst.) |
RM 82,000 |
|
5 |
Generation and characterisation of induced pluripotent stem cells from a leukaemia cell line |
Dr. Leong PP (PI) Prof. Dr. Cheong SK A/Prof. Dr. Alan Ong |
RM 62,000 |
|
6 |
Thermosensitive microcarriers for non-invasive detachment of anchorage-dependent human mesenchymal stem cells |
A/Prof. Dr. Lim YM (PI) Prof. Dr. Cheong SK |
RM 64,000 |
|
7 |
Regulation of expression of microRNA-515 gene family in induced-pluripotent stem cells (iPSCs) |
Prof. Dr. Choo KB (PI) Prof. Dr. Huang CJ (Chinese Culture Uni, Taipei) Dr. S. Sugii (SBIC, Singapore) |
RM 101,000 (July, 2013 – June, 2014) |
|
8 |
Generation of induced pluripotent stem cell (iPSC) from mesenchymal stem cell (MSC) |
Prof. Dr. Choo KB (PI) Prof. Dr. Cheong SK Dr. S. Sugii (SBIC, Singapore) |
RM 27,500 (Jan 2013 – Dec 2013 |
|
9 |
MicroRNA profiling and regulation in human colon cancer |
Prof. Dr. Choo KB (PI) Prof. Dr. Huang CJ (Chinese Culture Uni, Taipei) |
RM 59,000 (July 2012 –June 2013) |
|
10 |
Generation and characterisation of spheroid cultures of colon cancer stem cells
|
Prof. Dr. Shelly Soo (PI) Prof. Dr. Choo KB |
RM 63,000 (July, 2013 – June, 2014) |